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pentobarbital will reduce the extent or result of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Pitolisant publicity is decreased by fifty% if coadministered with robust CYP3A4 inducers.pentobarbital will lessen the extent or effect of diclofenac by impacting hepatic enzyme CYP2C9/10 metaboli